full Prescribing Information and Medication Guide, including With ACTEMRA IV infusions, you may be able to treat your moderate to severe RA with or without. Full Prescribing Information ACTEMRA is indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have. Actemra® (tocilizumab) pre-filled syringe for subcutaneous (SC) injection. Patients Consumer Medicine Information (CMI). Healthcare Professionals.
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Anaphylaxis and other hypersensitivity reactions that required treatment discontinuation were reported in 0. This can make you more likely to get infections or make any current infection worse. Some people have serious infections while taking Informarion, including tuberculosis TBand infections caused by bacteria, fungi, or viruses that can spread throughout the body.
In the 6-month control period, in SC-I, the frequency of injection-site reactions was Serious allergic reactions Serious allergic reactions, including death, can happen with ACTEMRA infusions or injections, even if they did not occur with an earlier infusion or injection.
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The risks and benefits of treatment with ACTEMRA should be carefully considered prior to initiating therapy in patients with chronic or recurrent infection. The most common serious infections included pneumonia, urinary tract infection, cellulitis, herpes zoster, gastroenteritis, diverticulitis, sepsis and bacterial arthritis.
Demyelinating Disorders The impact of treatment with ACTEMRA on demyelinating disorders is not known, but multiple sclerosis and chronic inflammatory demyelinating polyneuropathy were reported rarely in clinical studies. The most commonly reported serious infections included pneumonia, gastroenteritis, varicella, and prescribinb media.
Contact immediately, as inforation as your presceibing provider or nurse, if you experience any of these reactions: Click “OK” if you are a healthcare professional. The majority resolved without any treatment and none necessitated drug discontinuation. Limited wctemra data in pregnant women are not sufficient to determine whether there is a drug-associated risk for major birth defects and miscarriage.
Neutrophils are white blood cells catemra help the body fight infection low platelet count. Gastrointestinal Perforations Events of gastrointestinal GI perforation have been reported in clinical trials, primarily as complications of diverticulitis in RA patients.
This can make you more likely to get infections or make any current infection worse. No information is available on presence of tocilizumab in human milk, the effects of drug on breastfed infant, or effects of drug on milk production.
Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites. Pharmacology Mechanism of Action Interleukin-6 receptor antagonist; changes in clinical trials observed include decreased C-reactive protein level to within normal range, decreased values in other pharmacodynamic parameters eg, rheumatoid factor, erythrocyte sedimentation rate, amyloid Aand increased hemoglobin value. If particulates and discoloration are noted, ingormation product should not be used.
The rate of serious infections was 9. Quantity Limits Drugs that have quantity limits associated with each prescription. The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc.
In PJIA patients, infusion-related reactions are defined as all events occurring during or within 24 hours prescribibg an infusion. Forms and Documents Here you can download the form you need to enroll in Genentech Rheumatology Access Solutions and other important information. Withdraw a volume of 0. You do not have to fill out any information on this form. Dilute to mL in 0.
Prior Authorization Drugs that require prior authorization. By clicking send, you acknowledge that you have permission to email the recipient with this information.
ACTEMRA® RA Treatment Information for Rheumatologists
Promptly evaluate patients presenting with new-onset abdominal symptoms for early identification of GI perforation. Belimumab Benlysta Medication Guide: Infliximab Remicade Medication Guide: Most commonly, these are “preferred” on formulary brand drugs.
For ACTEMRA subcutaneous injection, advise patients to seek immediate medical attention if they experience any symptoms of a hypersensitivity reaction. If you log prescribinv, you will be required to enter your username and password the next time you visit. Do not dilute vials until after successfully obtaining intravenous access.
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May be used alone following discontinuation of glucocorticoids eg, interruption of dosing may be needed for management of dose-related laboratory abnormalities, IV administration is not approved for GCA. Tell your healthcare provider right away if you see any of these side effects: Maternal immunoglobulin G IgG is present in human milk; if tocilizumab is transferred into human milk, effects of local exposure in gastrointestinal tract and potential limited systemic exposure in infant to tocilizumab are unknown.
Monoclonal antibodies are increasingly transported across informatino as pregnancy progresses, with largest amount transferred during third trimester; risks and benefits should be considered prior to administering live or live-attenuated vaccines to infants exposed to therapy in utero. Dose interruptions ingormation recommended for liver enzyme abnormalities, low neutrophil counts, and low platelet counts in patients with PJIA and SJIA at acteemra similar to what is outlined for adults with RA.
Sign Up It’s Free! The American College of Rheumatology is providing this information as a benefit and service in furtherance of its educational mission. Controlled studies in pregnant women show no evidence of fetal risk. If a serious infection develops, interrupt tocilizumab until the infection is controlled. The information contained in this section of the site is intended for U.
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To learn more, call or talk to your healthcare provider to register. Adding plans allows you to compare formulary status to other drugs in the same class. Laboratory monitoring — recommended due to potential consequences of treatment-related changes in neutrophils, platelets, lipids and liver specific enzymes.